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The aspect of WSN is not strongly pathognomonic. It's important to perform careful clinical and histological examinations to differentiate this benign condition from other potentially pre-malignant lesions as well as oral lichen planus, keratosis follicularis, candidiasis, lichenoid reactions and lupus erythematosus12.. Institutional Review Board approval was obtained. Tumor registry data identified patients diagnosed with gall bladder carcinoma at a single institution between the years of 1998 and 2005. We performed a retrospective review of these consecutive patients' charts and obtained the following information: biopsy site, stage at diagnosis, treatment modalities, survival, and tumor grade. Cell blocks were then obtained from pathology archives and stained for EGFR and Her2/neu as described below.